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Chen,
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
2013, Pubmed,
Xenbase
Chen,
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.
2013,
Pubmed
,
Xenbase Di Virgilio,
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin.
2009,
Pubmed
,
Xenbase Huen,
Assembly of checkpoint and repair machineries at DNA damage sites.
2010,
Pubmed Iliuk,
Chemical visualization of phosphoproteomes on membrane.
2012,
Pubmed Kim,
Protein kinase CK2 interacts with Chk2 and phosphorylates Mre11 on serine 649.
2005,
Pubmed Koppensteiner,
Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro.
2014,
Pubmed Lee,
Recent Advances and New Strategies in Targeting Plk1 for Anticancer Therapy.
2015,
Pubmed Lee,
Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.
2003,
Pubmed Li,
Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments.
2010,
Pubmed Liu,
Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
2012,
Pubmed Liu,
Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery.
2010,
Pubmed Liu,
Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment.
2015,
Pubmed Macůrek,
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery.
2008,
Pubmed Mamely,
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.
2006,
Pubmed Milman,
Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes.
2009,
Pubmed Olive,
The comet assay: a method to measure DNA damage in individual cells.
2006,
Pubmed Olson,
The Mre11-Rad50-Nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and Rad3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment.
2007,
Pubmed Paull,
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.
1999,
Pubmed Paull,
A mechanistic basis for Mre11-directed DNA joining at microhomologies.
2000,
Pubmed Paull,
The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
1998,
Pubmed Qin,
Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein.
2013,
Pubmed
,
Xenbase Rödel,
Polo-like kinase 1 as predictive marker and therapeutic target for radiotherapy in rectal cancer.
2010,
Pubmed Smits,
Polo-like kinase-1 is a target of the DNA damage checkpoint.
2000,
Pubmed Steegmaier,
BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.
2007,
Pubmed Stewart,
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder.
1999,
Pubmed Strebhardt,
Thoughts on the current assessment of Polo-like kinase inhibitor drug discovery.
2015,
Pubmed Strebhardt,
Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.
2010,
Pubmed van Attikum,
Crosstalk between histone modifications during the DNA damage response.
2009,
Pubmed van Vugt,
Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells.
2004,
Pubmed van Vugt,
A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.
2010,
Pubmed Willis,
Study of the DNA damage checkpoint using Xenopus egg extracts.
2012,
Pubmed
,
Xenbase Wu,
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.
2008,
Pubmed Yata,
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
2012,
Pubmed Zhuang,
Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.
2009,
Pubmed
