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XB-ART-55022
Methods Mol Biol 2018 Jan 01;1797:309-323. doi: 10.1007/978-1-4939-7883-0_16.
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Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays.



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Amphibian embryos have long served as an ideal model for teratogenicity testing. While whole-mount embryo observations can be utilized, histological observation of teratogenic phenotypes provides a wealth of additional information that can lead to mechanistic insights. In this chapter, detailed protocols for two methods of sectioning embryos as well as a guide for histological analysis is provided.

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Species referenced: Xenopus laevis

References [+] :
Bonfanti, Comparative teratogenicity of chlorpyrifos and malathion on Xenopus laevis development. 2004, Pubmed, Xenbase