Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Toxicol Sci
2018 Nov 01;1661:39-50. doi: 10.1093/toxsci/kfy179.
Show Gene links
Show Anatomy links
Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.
Robert J, McGuire CC, Kim F, Nagel SC, Price SJ, Lawrence BP, De Jesús Andino F.
???displayArticle.abstract???
Chemicals associated with unconventional oil and gas (UOG) operations have been shown to contaminate surface and ground water with a variety of endocrine disrupting compounds (EDCs) inducing multiple developmental alteration in mice. However, little is known about the impacts of UOG-associated contaminants on amphibian health and resistance to an emerging ranavirus infectious disease caused by viruses in the genus Ranavirus, especially at the vulnerable tadpole stage. Here we used tadpoles of the amphibian Xenopus laevis and the ranavirus Frog virus 3 (FV3) as a model relevant to aquatic environment conservation research for investigating the immunotoxic effects of exposure to a mixture of 23 UOG-associated chemicals with EDC activity. Xenopus tadpoles were exposed to an equimass mixture of 23 UOG-associated chemicals (range from 0.1 to 10 µg/l) for 3 weeks prior to infection with FV3. Our data show that exposure to the UOG chemical mixture is toxic for tadpoles at ecological doses of 5 to 10 µg/l. Lower doses significantly altered homeostatic expression of myeloid lineage genes and compromised tadpole responses to FV3 through expression of TNF-α, IL-1β, and Type I IFN genes, correlating with an increase in viral load. Exposure to a subset of 6 UOG chemicals was still sufficient to perturb the antiviral gene expression response. These findings suggest that UOG-associated water pollutants at low but environmentally relevant doses have the potential to induce acute alterations of immune function and antiviral immunity.
Bahadar,
Current understandings and perspectives on non-cancer health effects of benzene: a global concern.
2014, Pubmed
Bahadar,
Current understandings and perspectives on non-cancer health effects of benzene: a global concern.
2014,
Pubmed Bandín,
Host range, host specificity and hypothesized host shift events among viruses of lower vertebrates.
2011,
Pubmed Bolden,
New Look at BTEX: Are Ambient Levels a Problem?
2015,
Pubmed Boulé,
Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice.
2018,
Pubmed Brand,
Water Temperature Affects Susceptibility to Ranavirus.
2016,
Pubmed Briskin,
Potential impacts of hydraulic fracturing for oil and gas on drinking water resources.
2015,
Pubmed Carpenter,
Hydraulic fracturing for natural gas: impact on health and environment.
2016,
Pubmed Chinchar,
Family Iridoviridae: poor viral relations no longer.
2009,
Pubmed Chinchar,
Ranaviruses (family Iridoviridae): emerging cold-blooded killers.
2002,
Pubmed Cozzarelli,
Environmental signatures and effects of an oil and gas wastewater spill in the Williston Basin, North Dakota.
2017,
Pubmed Daszak,
Emerging infectious diseases and amphibian population declines.
1999,
Pubmed De Jesús Andino,
Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis.
2017,
Pubmed
,
Xenbase De Jesús Andino,
Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.
2012,
Pubmed
,
Xenbase DiGiulio,
Impact to Underground Sources of Drinking Water and Domestic Wells from Production Well Stimulation and Completion Practices in the Pavillion, Wyoming, Field.
2016,
Pubmed Edholm,
Evolutionary Aspects of Macrophages Polarization.
2017,
Pubmed Egea-Serrano,
Understanding of the impact of chemicals on amphibians: a meta-analytic review.
2012,
Pubmed Elsner,
Quantitative Survey and Structural Classification of Hydraulic Fracturing Chemicals Reported in Unconventional Gas Production.
2016,
Pubmed Fail,
General, reproductive, developmental, and endocrine toxicity of boronated compounds.
1998,
Pubmed Grayfer,
Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver.
2013,
Pubmed
,
Xenbase Grayfer,
Distinct functional roles of amphibian (Xenopus laevis) colony-stimulating factor-1- and interleukin-34-derived macrophages.
2015,
Pubmed
,
Xenbase Grayfer,
Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus.
2015,
Pubmed
,
Xenbase Grayfer,
Divergent antiviral roles of amphibian (Xenopus laevis) macrophages elicited by colony-stimulating factor-1 and interleukin-34.
2014,
Pubmed
,
Xenbase Grayfer,
The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity.
2014,
Pubmed
,
Xenbase Grayfer,
Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens.
2012,
Pubmed
,
Xenbase Greer,
Five amphibian mortality events associated with ranavirus infection in south central Ontario, Canada.
2005,
Pubmed Gross,
Analysis of BTEX groundwater concentrations from surface spills associated with hydraulic fracturing operations.
2013,
Pubmed Jancovich,
Evidence for multiple recent host species shifts among the Ranaviruses (family Iridoviridae).
2010,
Pubmed Kassotis,
Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice.
2016,
Pubmed Kassotis,
Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region.
2014,
Pubmed Kassotis,
Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations: Potential Environmental Contamination and Recommendations to Assess Complex Environmental Mixtures.
2016,
Pubmed Kassotis,
Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice.
2015,
Pubmed Kassotis,
Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site.
2016,
Pubmed Koubourli,
Immune roles of amphibian (Xenopus laevis) tadpole granulocytes during Frog Virus 3 ranavirus infections.
2017,
Pubmed
,
Xenbase Miyata,
Thyroid Hormone-disrupting Effects and the Amphibian Metamorphosis Assay.
2012,
Pubmed
,
Xenbase Mrdjen,
High volume hydraulic fracturing operations: potential impacts on surface water and human health.
2016,
Pubmed National Toxicology Program,
Toxicology and carcinogenesis studies of cumene (CAS No. 98-82-8) in F344/N rats and B6C3F1 mice (inhalation studies).
2009,
Pubmed NULL,
Complete sequence and gene map of a human major histocompatibility complex. The MHC sequencing consortium.
1999,
Pubmed Pongsavee,
Genotoxic effects of borax on cultured lymphocytes.
2009,
Pubmed Price,
From fish to frogs and beyond: Impact and host range of emergent ranaviruses.
2017,
Pubmed Sapouckey,
Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice.
2018,
Pubmed Sifkarovski,
Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis.
2014,
Pubmed
,
Xenbase Stuart,
Status and trends of amphibian declines and extinctions worldwide.
2004,
Pubmed Vengosh,
A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States.
2014,
Pubmed Veraldi,
Immunotoxic effects of chemicals: A matrix for occupational and environmental epidemiological studies.
2006,
Pubmed Webb,
Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations.
2014,
Pubmed Wilkin,
Geochemical impacts to groundwater from geologic carbon sequestration: controls on pH and inorganic carbon concentrations from reaction path and kinetic modeling.
2010,
Pubmed Yu,
Singapore grouper iridovirus (SGIV) TNFR homolog VP51 functions as a virulence factor via modulating host inflammation response.
2017,
Pubmed
