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Sci Total Environ
2019 Jun 25;671:644-654. doi: 10.1016/j.scitotenv.2019.03.395.
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Developmental exposure to chemicals associated with unconventional oil and gas extraction alters immune homeostasis and viral immunity of the amphibian Xenopus.
Robert J, McGuire CC, Nagel S, Lawrence BP, Andino FJ.
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Although aquatic vertebrates and humans are increasingly exposed to water pollutants associated with unconventional oil and gas extraction (UOG), the long-term effects of these pollutants on immunity remains unclear. We have established the amphibian Xenopus laevis and the ranavirus Frog Virus 3 (FV3) as a reliable and sensitive model for evaluating the effects of waterborne pollutants. X. laevis tadpoles were exposed to a mixture of equimass amount of UOG chemicals with endocrine disrupting activity (0.1 and 1.0 μg/L) for 3 weeks, and then long-term effects on immune function at steady state and following viral (FV3) infection was assessed after metamorphosis. Notably, developmental exposure to the mixture of UOG chemicals at the tadpole stage affected metamorphic development and fitness by significantly decreasing body mass after metamorphosis completion. Furthermore, developmental exposure to UOGs resulted in perturbation of immune homeostasis in adult frogs, as indicated by significantly decreased number of splenic innate leukocytes, B and T lymphocytes; and a weakened antiviral immune response leading to increased viral load during infection by the ranavirus FV3. These findings suggest that mixture of UOG-associated waterborne endocrine disruptors at low but environmentally-relevant levels have the potential to induce long-lasting alterations of immune function and antiviral immunity in aquatic vertebrates and ultimately human populations.
Bandín,
Host range, host specificity and hypothesized host shift events among viruses of lower vertebrates.
2011, Pubmed
Bandín,
Host range, host specificity and hypothesized host shift events among viruses of lower vertebrates.
2011,
Pubmed Bansal,
Immune System: An Emerging Player in Mediating Effects of Endocrine Disruptors on Metabolic Health.
2018,
Pubmed Blom,
Immune-Neuroendocrine Interactions: Evolution, Ecology, and Susceptibility to Illness.
2017,
Pubmed Boulé,
Developmental Exposure to a Mixture of 23 Chemicals Associated With Unconventional Oil and Gas Operations Alters the Immune System of Mice.
2018,
Pubmed Carpenter,
Hydraulic fracturing for natural gas: impact on health and environment.
2016,
Pubmed Casey,
Unconventional Natural Gas Development and Birth Outcomes in Pennsylvania, USA.
2016,
Pubmed Chen,
Antiviral immunity in amphibians.
2011,
Pubmed
,
Xenbase Chida,
Phylogenetic and developmental study of CD4, CD8 α and β T cell co-receptor homologs in two amphibian species, Xenopus tropicalis and Xenopus laevis.
2011,
Pubmed
,
Xenbase Chinchar,
Family Iridoviridae: poor viral relations no longer.
2009,
Pubmed Chinchar,
Ranaviruses (family Iridoviridae): emerging cold-blooded killers.
2002,
Pubmed Cozzarelli,
Environmental signatures and effects of an oil and gas wastewater spill in the Williston Basin, North Dakota.
2017,
Pubmed Crosby,
Toxicological and chemical studies of wastewater from hydraulic fracture and conventional shale gas wells.
2018,
Pubmed De Jesús Andino,
Long term effects of carbaryl exposure on antiviral immune responses in Xenopus laevis.
2017,
Pubmed
,
Xenbase De Jesús Andino,
Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs.
2012,
Pubmed
,
Xenbase DiGiulio,
Impact to Underground Sources of Drinking Water and Domestic Wells from Production Well Stimulation and Completion Practices in the Pavillion, Wyoming, Field.
2016,
Pubmed Du Pasquier,
Expression of MHC class II antigens during Xenopus development.
1990,
Pubmed
,
Xenbase Edholm,
Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians.
2013,
Pubmed
,
Xenbase Edholm,
Flow Cytometric Analysis of Xenopus Immune Cells.
2018,
Pubmed
,
Xenbase Elsner,
Quantitative Survey and Structural Classification of Hydraulic Fracturing Chemicals Reported in Unconventional Gas Production.
2016,
Pubmed Fini,
Parallel biotransformation of tetrabromobisphenol A in Xenopus laevis and mammals: Xenopus as a model for endocrine perturbation studies.
2012,
Pubmed
,
Xenbase Flajnik,
Evolution of the MHC: antigenicity and unusual tissue distribution of Xenopus (frog) class II molecules.
1990,
Pubmed
,
Xenbase Gantress,
Development and characterization of a model system to study amphibian immune responses to iridoviruses.
2003,
Pubmed
,
Xenbase Greer,
Five amphibian mortality events associated with ranavirus infection in south central Ontario, Canada.
2005,
Pubmed Gross,
Analysis of BTEX groundwater concentrations from surface spills associated with hydraulic fracturing operations.
2013,
Pubmed Holling,
Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men.
2004,
Pubmed Horton,
Xenopus NK cells identified by novel monoclonal antibodies.
2000,
Pubmed
,
Xenbase Hua,
The contribution of phenotypic plasticity to the evolution of insecticide tolerance in amphibian populations.
2015,
Pubmed Jacques,
Xenopus-FV3 host-pathogen interactions and immune evasion.
2017,
Pubmed
,
Xenbase Jancovich,
Evidence for multiple recent host species shifts among the Ranaviruses (family Iridoviridae).
2010,
Pubmed Kassotis,
Adverse Reproductive and Developmental Health Outcomes Following Prenatal Exposure to a Hydraulic Fracturing Chemical Mixture in Female C57Bl/6 Mice.
2016,
Pubmed Kassotis,
Estrogen and androgen receptor activities of hydraulic fracturing chemicals and surface and ground water in a drilling-dense region.
2014,
Pubmed Kassotis,
Characterization of Missouri surface waters near point sources of pollution reveals potential novel atmospheric route of exposure for bisphenol A and wastewater hormonal activity pattern.
2015,
Pubmed Kassotis,
Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice.
2015,
Pubmed Kassotis,
Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site.
2016,
Pubmed Kassotis,
Endocrine-Disrupting Chemicals and Oil and Natural Gas Operations: Potential Environmental Contamination and Recommendations to Assess Complex Environmental Mixtures.
2016,
Pubmed Kinney,
Neural-immune system interactions in Xenopus.
2009,
Pubmed
,
Xenbase Kuo,
Immunomodulatory effects of environmental endocrine disrupting chemicals.
2012,
Pubmed Lavine,
Aryl hydrocarbon receptors in the frog Xenopus laevis: two AhR1 paralogs exhibit low affinity for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
2005,
Pubmed
,
Xenbase Maniero,
Generation of a long-lasting, protective, and neutralizing antibody response to the ranavirus FV3 by the frog Xenopus.
2006,
Pubmed
,
Xenbase Morales,
Characterization of primary and memory CD8 T-cell responses against ranavirus (FV3) in Xenopus laevis.
2007,
Pubmed
,
Xenbase Morales,
Innate immune responses and permissiveness to ranavirus infection of peritoneal leukocytes in the frog Xenopus laevis.
2010,
Pubmed
,
Xenbase Mrdjen,
High volume hydraulic fracturing operations: potential impacts on surface water and human health.
2016,
Pubmed Neely,
"Double-duty" conventional dendritic cells in the amphibian Xenopus as the prototype for antigen presentation to B cells.
2018,
Pubmed
,
Xenbase Quatrini,
Neuroendocrine regulation of innate lymphoid cells.
2018,
Pubmed Robert,
Water Contaminants Associated With Unconventional Oil and Gas Extraction Cause Immunotoxicity to Amphibian Tadpoles.
2018,
Pubmed
,
Xenbase Robert,
Adaptive immunity and histopathology in frog virus 3-infected Xenopus.
2005,
Pubmed
,
Xenbase Robert,
Comparative and developmental study of the immune system in Xenopus.
2009,
Pubmed
,
Xenbase Rollins-Smith,
Expression of class II major histocompatibility complex antigens on adult T cells in Xenopus is metamorphosis-dependent.
1990,
Pubmed
,
Xenbase Sapouckey,
Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice.
2018,
Pubmed Sifkarovski,
Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis.
2014,
Pubmed
,
Xenbase Unanue,
Variations in MHC Class II Antigen Processing and Presentation in Health and Disease.
2016,
Pubmed Vandenberg,
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.
2012,
Pubmed Vengosh,
A critical review of the risks to water resources from unconventional shale gas development and hydraulic fracturing in the United States.
2014,
Pubmed Webb,
Developmental and reproductive effects of chemicals associated with unconventional oil and natural gas operations.
2014,
Pubmed Wilkin,
Geochemical impacts to groundwater from geologic carbon sequestration: controls on pH and inorganic carbon concentrations from reaction path and kinetic modeling.
2010,
Pubmed
