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Comparative analyses suggest that the MHC was derived from a prevertebrate "primordial immune complex" (PIC). PIC duplicated twice in the well-studied two rounds of genome-wide duplications (2R) early in vertebrate evolution, generating four MHC paralogous regions (predominantly on human chromosomes [chr] 1, 6, 9, 19). Examining chiefly the amphibian Xenopus laevis, but also other vertebrates, we identified their MHC paralogues and mapped MHC class I, AgR, and "framework" genes. Most class I genes mapped to MHC paralogues, but a cluster of Xenopus MHC class Ib genes (xnc), which previously was mapped outside of the MHC paralogues, was surrounded by genes syntenic to mammalian CD1 genes, a region previously proposed as an MHC paralogue on human chr 1. Thus, this gene block is instead the result of a translocation that we call the translocated part of the MHC paralogous region (MHCtrans) Analyses of Xenopus class I genes, as well as MHCtrans, suggest that class I arose at 1R on the chr 6/19 ancestor. Of great interest are nonrearranging AgR-like genes mapping to three MHC paralogues; thus, PIC clearly contained several AgR precursor loci, predating MHC class I/II. However, all rearranging AgR genes were found on paralogues derived from the chr 19 precursor, suggesting that invasion of a variable (V) exon by the RAG transposon occurred after 2R. We propose models for the evolutionary history of MHC/TCR/Ig and speculate on the dichotomy between the jawless (lamprey and hagfish) and jawed vertebrate adaptive immune systems, as we found genes related to variable lymphocyte receptors also map to MHC paralogues.
Abi Rached,
The MHC big bang.
1999,
Pubmed Abi-Rached,
Evidence of en bloc duplication in vertebrate genomes.
2002,
Pubmed Agrawal,
Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system.
1998,
Pubmed Anderson,
Establishment of dorsal-ventral polarity in the Drosophila embryo: genetic studies on the role of the Toll gene product.
1985,
Pubmed Anderson,
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product.
1985,
Pubmed Bartl,
Identification of class I genes in cartilaginous fish, the most ancient group of vertebrates displaying an adaptive immune response.
1997,
Pubmed Calabi,
A novel family of human major histocompatibility complex-related genes not mapping to chromosome 6.
,
Pubmed Chen,
Discovery and Analysis of Invertebrate IgVJ-C2 Structure from Amphioxus Provides Insight into the Evolution of the Ig Superfamily.
2018,
Pubmed Collette,
A co-evolution perspective of the TNFSF and TNFRSF families in the immune system.
2003,
Pubmed Courtet,
Major histocompatibility complex and immunoglobulin loci visualized by in situ hybridization on Xenopus chromosomes.
2001,
Pubmed
,
Xenbase Danchin,
Conservation of the MHC-like region throughout evolution.
2003,
Pubmed Danchin,
Towards the reconstruction of the bilaterian ancestral pre-MHC region.
2004,
Pubmed Darbo,
Evolution of major histocompatibility complex by "en bloc" duplication before mammalian radiation.
2008,
Pubmed Davis,
T-cell antigen receptor genes and T-cell recognition.
1988,
Pubmed Del Porto,
Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene.
1995,
Pubmed Dijkstra,
Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules.
2019,
Pubmed Donoviel,
Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN.
2001,
Pubmed Du Pasquier,
Speculations on the origin of the vertebrate immune system.
2004,
Pubmed Du Pasquier,
Several MHC-linked Ig superfamily genes have features of ancestral antigen-specific receptor genes.
2002,
Pubmed Du Pasquier,
Immunoglobulin superfamily receptors in protochordates: before RAG time.
2004,
Pubmed
,
Xenbase Du Pasquier,
The immune system of Xenopus.
1989,
Pubmed
,
Xenbase DuPasquier,
CTX, a new lymphocyte receptor in Xenopus, and the early evolution of Ig domains.
1996,
Pubmed
,
Xenbase Edholm,
Unusual evolutionary conservation and further species-specific adaptations of a large family of nonclassical MHC class Ib genes across different degrees of genome ploidy in the amphibian subfamily Xenopodinae.
2014,
Pubmed
,
Xenbase Edholm,
Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians.
2013,
Pubmed
,
Xenbase Edholm,
Evolution of innate-like T cells and their selection by MHC class I-like molecules.
2016,
Pubmed
,
Xenbase Edholm,
Distinct MHC class I-like interacting invariant T cell lineage at the forefront of mycobacterial immunity uncovered in Xenopus.
2018,
Pubmed
,
Xenbase Flajnik,
A novel type of class I gene organization in vertebrates: a large family of non-MHC-linked class I genes is expressed at the RNA level in the amphibian Xenopus.
1993,
Pubmed
,
Xenbase Flajnik,
Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus.
1984,
Pubmed
,
Xenbase Flajnik,
Origin and evolution of the adaptive immune system: genetic events and selective pressures.
2010,
Pubmed Flajnik,
Which came first, MHC class I or class II?
1991,
Pubmed Flajnik,
Comparative genomics of the MHC: glimpses into the evolution of the adaptive immune system.
2001,
Pubmed Flajnik,
Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.
2012,
Pubmed
,
Xenbase Flajnik,
A cold-blooded view of adaptive immunity.
2018,
Pubmed Fu,
Identification of Two Nonrearranging IgSF Genes in Chicken Reveals a Novel Family of Putative Remnants of an Antigen Receptor Precursor.
2019,
Pubmed Glusman,
Comparative genomics of the human and mouse T cell receptor loci.
2001,
Pubmed Godfrey,
Raising the NKT cell family.
2010,
Pubmed Guselnikov,
Diversity of the FcR- and KIR-related genes in an amphibian Xenopus.
2009,
Pubmed
,
Xenbase Guselnikov,
Expansion and diversification of the signaling capabilities of the CD2/SLAM family in Xenopodinae amphibians.
2011,
Pubmed
,
Xenbase Guselnikov,
The Xenopus FcR family demonstrates continually high diversification of paired receptors in vertebrate evolution.
2008,
Pubmed
,
Xenbase Hallböök,
Evolution of the vertebrate neurotrophin and Trk receptor gene families.
1999,
Pubmed Hellsten,
The genome of the Western clawed frog Xenopus tropicalis.
2010,
Pubmed
,
Xenbase Hoffmann,
Whole-genome duplications spurred the functional diversification of the globin gene superfamily in vertebrates.
2012,
Pubmed Hood,
T cell antigen receptors and the immunoglobulin supergene family.
1985,
Pubmed Horton,
Gene map of the extended human MHC.
2004,
Pubmed Hsu,
The invention of lymphocytes.
2011,
Pubmed Hughes,
Evolutionary relationships of the classes of major histocompatibility complex genes.
1993,
Pubmed Jayawardena-Wolf,
CD1 and lipid antigens: intracellular pathways for antigen presentation.
2001,
Pubmed Kasahara,
Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.
1996,
Pubmed Kasahara,
New insights into the genomic organization and origin of the major histocompatibility complex: role of chromosomal (genome) duplication in the emergence of the adaptive immune system.
1997,
Pubmed Kasahara,
The chromosomal duplication model of the major histocompatibility complex.
1999,
Pubmed Kasahara,
Chromosomal duplication and the emergence of the adaptive immune system.
1997,
Pubmed Kaufman,
The chicken B locus is a minimal essential major histocompatibility complex.
1999,
Pubmed Kaufman,
Co-evolution with chicken class I genes.
2015,
Pubmed Kaufman,
Unfinished Business: Evolution of the MHC and the Adaptive Immune System of Jawed Vertebrates.
2018,
Pubmed Kaufman,
The class II molecules of the human and murine major histocompatibility complex.
1984,
Pubmed Kelley,
Comparative genomics of major histocompatibility complexes.
2005,
Pubmed Krasnec,
The UT family of MHC class I loci unique to non-eutherian mammals has limited polymorphism and tissue specific patterns of expression in the opossum.
2016,
Pubmed Lundin,
Evolution of the vertebrate genome as reflected in paralogous chromosomal regions in man and the house mouse.
1993,
Pubmed Martin,
Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens.
1986,
Pubmed Maruoka,
Chicken CD1 genes are located in the MHC: CD1 and endothelial protein C receptor genes constitute a distinct subfamily of class-I-like genes that predates the emergence of mammals.
2005,
Pubmed McConnell,
Alternative haplotypes of antigen processing genes in zebrafish diverged early in vertebrate evolution.
2016,
Pubmed Miller,
Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
2005,
Pubmed Miller,
Brief review of the chicken Major Histocompatibility Complex: the genes, their distribution on chromosome 16, and their contributions to disease resistance.
2016,
Pubmed Nonaka,
Trans-species polymorphism of the major histocompatibility complex-encoded proteasome subunit LMP7 in an amphibian genus, Xenopus.
2000,
Pubmed
,
Xenbase Nonaka,
Major histocompatibility complex gene mapping in the amphibian Xenopus implies a primordial organization.
1997,
Pubmed
,
Xenbase Oettinger,
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination.
1990,
Pubmed Ohta,
Two highly divergent ancient allelic lineages of the transporter associated with antigen processing (TAP) gene in Xenopus: further evidence for co-evolution among MHC class I region genes.
2003,
Pubmed
,
Xenbase Ohta,
Coevolution of MHC genes (LMP/TAP/class Ia, NKT-class Ib, NKp30-B7H6): lessons from cold-blooded vertebrates.
2015,
Pubmed
,
Xenbase Ohta,
Ancestral organization of the MHC revealed in the amphibian Xenopus.
2006,
Pubmed
,
Xenbase Ohta,
Primordial linkage of β2-microglobulin to the MHC.
2011,
Pubmed Olinski,
Conserved synteny between the Ciona genome and human paralogons identifies large duplication events in the molecular evolution of the insulin-relaxin gene family.
2006,
Pubmed Pancer,
Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey.
2004,
Pubmed Parra,
The dynamic TCRδ: TCRδ chains in the amphibian Xenopus tropicalis utilize antibody-like V genes.
2010,
Pubmed
,
Xenbase Pende,
Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.
1999,
Pubmed Rogers,
Location, location, location: the evolutionary history of CD1 genes and the NKR-P1/ligand systems.
2016,
Pubmed Rogozin,
Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase.
2007,
Pubmed Saint-Ruf,
Analysis and expression of a cloned pre-T cell receptor gene.
1994,
Pubmed Salomonsen,
Two CD1 genes map to the chicken MHC, indicating that CD1 genes are ancient and likely to have been present in the primordial MHC.
2005,
Pubmed Schatz,
The V(D)J recombination activating gene, RAG-1.
1989,
Pubmed Session,
Genome evolution in the allotetraploid frog Xenopus laevis.
2016,
Pubmed
,
Xenbase Shum,
Isolation of a classical MHC class I cDNA from an amphibian. Evidence for only one class I locus in the Xenopus MHC.
1993,
Pubmed
,
Xenbase Suurväli,
The proto-MHC of placozoans, a region specialized in cellular stress and ubiquitination/proteasome pathways.
2014,
Pubmed Tanaka,
The proteasome: from basic mechanisms to emerging roles.
2013,
Pubmed Trowsdale,
Genetic and functional relationships between MHC and NK receptor genes.
2001,
Pubmed Tsukamoto,
Dichotomous haplotypic lineages of the immunoproteasome subunit genes, PSMB8 and PSMB10, in the MHC class I region of a Teleost Medaka, Oryzias latipes.
2009,
Pubmed Uno,
Homoeologous chromosomes of Xenopus laevis are highly conserved after whole-genome duplication.
2013,
Pubmed
,
Xenbase Williams,
The immunoglobulin superfamily--domains for cell surface recognition.
1988,
Pubmed Wu,
Phylogeny, genomic organization and expression of lambda and kappa immunoglobulin light chain genes in a reptile, Anolis carolinensis.
2010,
Pubmed Yang,
Analysis of the reptile CD1 genes: evolutionary implications.
2015,
Pubmed Zajonc,
The CD1 family: serving lipid antigens to T cells since the Mesozoic era.
2016,
Pubmed
