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???displayArticle.abstract??? Dishevelled proteins are key players of Wnt signaling pathways. They transduce Wnt signals and perform cellular functions through distinct conserved domains. Due to the presence of multiple paralogs, the abundant accumulation of maternal transcripts, and the activation of distinct Wnt pathways, their regulatory roles during vertebrate early development and the mechanism by which they dictate the pathway specificity have been enigmatic and attracted much attention in the past decades. Extensive studies in different animal models have provided significant insights into the structure-function relationship of conserved Dishevelled domains in Wnt signaling and the implications of Dishevelled isoforms in early developmental processes. Notably, intra- and inter-molecular interactions and Dishevelled dosage may be important in modulating the specificity of Wnt signaling. There are also distinct and redundant functions among Dishevelled isoforms in development and disease, which may result from differential spatiotemporal expression patterns and biochemical properties and post-translational modifications. This review presents the advances and perspectives in understanding Dishevelled-mediated Wnt signaling during gastrulation and neurulation in vertebrate early embryos.
Axelrod,
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
1998, Pubmed,
Xenbase
Axelrod,
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways.
1998,
Pubmed
,
Xenbase Belinson,
Prenatal β-catenin/Brn2/Tbr2 transcriptional cascade regulates adult social and stereotypic behaviors.
2016,
Pubmed Bellipanni,
Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectoderm.
2006,
Pubmed Boutros,
Dishevelled: at the crossroads of divergent intracellular signaling pathways.
1999,
Pubmed
,
Xenbase Bunn,
Mutations in DVL1 cause an osteosclerotic form of Robinow syndrome.
2015,
Pubmed Butler,
Planar cell polarity in development and disease.
2017,
Pubmed Carron,
Specification of anteroposterior axis by combinatorial signaling during Xenopus development.
2016,
Pubmed
,
Xenbase Cheng,
Leucine repeat adaptor protein 1 interacts with Dishevelled to regulate gastrulation cell movements in zebrafish.
2017,
Pubmed
,
Xenbase Clevers,
Wnt/β-catenin signaling and disease.
2012,
Pubmed Danyel,
Autosomal dominant Robinow syndrome associated with a novel DVL3 splice mutation.
2018,
Pubmed De Marco,
Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.
2013,
Pubmed Djiane,
Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis.
2000,
Pubmed
,
Xenbase Etheridge,
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
2008,
Pubmed Fuentes,
The maternal coordinate system: Molecular-genetics of embryonic axis formation and patterning in the zebrafish.
2020,
Pubmed Gammons,
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.
2016,
Pubmed Gammons,
Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.
2016,
Pubmed Gao,
Dishevelled: The hub of Wnt signaling.
2010,
Pubmed Gentzel,
Dishevelled Paralogs in Vertebrate Development: Redundant or Distinct?
2017,
Pubmed
,
Xenbase Gentzel,
Distinct functionality of dishevelled isoforms on Ca2+/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation.
2015,
Pubmed
,
Xenbase Gray,
Diversification of the expression patterns and developmental functions of the dishevelled gene family during chordate evolution.
2009,
Pubmed
,
Xenbase Green,
The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction.
2014,
Pubmed Habas,
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
2001,
Pubmed
,
Xenbase Habas,
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation.
2003,
Pubmed
,
Xenbase Hamblet,
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.
2002,
Pubmed Hanáková,
Comparative phosphorylation map of Dishevelled 3 links phospho-signatures to biological outputs.
2019,
Pubmed Harnoš,
Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1.
2019,
Pubmed
,
Xenbase Harrison,
Molecular mechanisms mediating asymmetric subcellular localisation of the core planar polarity pathway proteins.
2020,
Pubmed Harvey,
Identification of the zebrafish maternal and paternal transcriptomes.
2013,
Pubmed Humphries,
From instruction to output: Wnt/PCP signaling in development and cancer.
2018,
Pubmed Jiang,
Novel Regulation of Wnt Signaling at the Proximal Membrane Level.
2016,
Pubmed Kan,
Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction.
2020,
Pubmed Keller,
Convergent extension in the amphibian, Xenopus laevis.
2020,
Pubmed
,
Xenbase Kelly,
Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish.
2000,
Pubmed Kimmel,
Specification and morphogenesis of the zebrafish larval head skeleton.
2001,
Pubmed Kishida,
DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.
1999,
Pubmed Kratzer,
The Rho guanine nucleotide exchange factor Trio is required for neural crest cell migration and interacts with Dishevelled.
2020,
Pubmed
,
Xenbase Lee,
Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways.
2015,
Pubmed
,
Xenbase Lehoczky,
Rethinking WNT signalling.
2018,
Pubmed Li,
Direct regulation of siamois by VegT is required for axis formation in Xenopus embryo.
2015,
Pubmed
,
Xenbase Lijam,
Social interaction and sensorimotor gating abnormalities in mice lacking Dvl1.
1997,
Pubmed Liu,
DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.
2020,
Pubmed Ma,
Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.
2010,
Pubmed Ma,
Single-molecule dynamics of Dishevelled at the plasma membrane and Wnt pathway activation.
2020,
Pubmed Marlow,
Setting up for gastrulation in zebrafish.
2020,
Pubmed Mlodzik,
The Dishevelled Protein Family: Still Rather a Mystery After Over 20 Years of Molecular Studies.
2016,
Pubmed Ngo,
Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.
2020,
Pubmed Niehrs,
The complex world of WNT receptor signalling.
2012,
Pubmed Paclíková,
The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/β-Catenin Signaling in Mammalian Cells.
2017,
Pubmed Pan,
Characterization of function of three domains in dishevelled-1: DEP domain is responsible for membrane translocation of dishevelled-1.
2004,
Pubmed Park,
Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.
2005,
Pubmed
,
Xenbase Qi,
Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways.
2017,
Pubmed
,
Xenbase Rauschenberger,
The phosphatase Pgam5 antagonizes Wnt/β-Catenin signaling in embryonic anterior-posterior axis patterning.
2017,
Pubmed
,
Xenbase Rothbächer,
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.
2000,
Pubmed
,
Xenbase Seo,
Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis.
2017,
Pubmed
,
Xenbase Sharma,
Dishevelled: A masterful conductor of complex Wnt signals.
2018,
Pubmed
,
Xenbase Shimizu,
Hipk2 and PP1c cooperate to maintain Dvl protein levels required for Wnt signal transduction.
2014,
Pubmed Sinha,
Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis.
2012,
Pubmed Soares,
Functional studies of signaling pathways in peri-implantation development of the mouse embryo by RNAi.
2005,
Pubmed Sokol,
Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled.
1995,
Pubmed
,
Xenbase Sokol,
Analysis of Dishevelled signalling pathways during Xenopus development.
1996,
Pubmed
,
Xenbase Solnica-Krezel,
Maternal contributions to gastrulation in zebrafish.
2020,
Pubmed Steinhart,
Wnt signaling in development and tissue homeostasis.
2018,
Pubmed Stricker,
ROR-Family Receptor Tyrosine Kinases.
2017,
Pubmed Tada,
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.
2000,
Pubmed
,
Xenbase Tadjuidje,
The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo.
2011,
Pubmed
,
Xenbase Tauriello,
Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.
2012,
Pubmed
,
Xenbase Umbhauer,
The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling.
2000,
Pubmed
,
Xenbase Wallingford,
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity.
2005,
Pubmed Wallingford,
Neural tube closure requires Dishevelled-dependent convergent extension of the midline.
2002,
Pubmed
,
Xenbase Wallingford,
Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis.
2001,
Pubmed
,
Xenbase Wallingford,
Dishevelled controls cell polarity during Xenopus gastrulation.
2000,
Pubmed
,
Xenbase Wang,
Dishevelled C-terminus: prolyl and histidinyl motifs.
2012,
Pubmed Wang,
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation.
2006,
Pubmed
,
Xenbase White,
DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.
2016,
Pubmed White,
DVL1 frameshift mutations clustering in the penultimate exon cause autosomal-dominant Robinow syndrome.
2015,
Pubmed Wiese,
Wnt signalling: conquering complexity.
2018,
Pubmed Wong,
Structural basis of the recognition of the dishevelled DEP domain in the Wnt signaling pathway.
2000,
Pubmed Wong,
Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled.
2003,
Pubmed
,
Xenbase Wynshaw-Boris,
Dishevelled: in vivo roles of a multifunctional gene family during development.
2012,
Pubmed Xing,
Mutational analysis of dishevelled genes in zebrafish reveals distinct functions in embryonic patterning and gastrulation cell movements.
2018,
Pubmed Yan,
Maternal Huluwa dictates the embryonic body axis through β-catenin in vertebrates.
2018,
Pubmed
,
Xenbase
