Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
Olfaction is a crucial capability for most vertebrates and is realized through olfactory receptors in the nasal cavity. The enormous diversity of olfactory receptors has been created by gene duplication, following a birth-and-death model of evolution. The olfactory receptor genes of the amphibians have received relatively little attention up to now, although recent studies have increased the number of species for which data are available. This study analyzed the diversity and chromosomal distribution of the OR genes of three anuran species (Engystomops pustulosus, Bufo bufo and Hymenochirus boettgeri). The OR genes were identified through searches for homologies, and sequence filtering and alignment using bioinformatic tools and scripts. A high diversity of OR genes was found in all three species, ranging from 917 in B. bufo to 1194 in H. boettgeri, and a total of 2076 OR genes in E. pustulosus. Six OR groups were recognized using an evolutionary gene tree analysis. While E. pustulosus has one of the highest numbers of genes of the gamma group (which detect airborne odorants) yet recorded in an anuran, B. bufo presented the smallest number of pseudogene sequences ever identified, with no pseudogenes in either the beta or epsilon groups. Although H. boettgeri shares many morphological adaptations for an aquatic lifestyle with Xenopus, and presented a similar number of genes related to the detection of water-soluble odorants, it had comparatively far fewer genes related to the detection of airborne odorants. This study is the first to describe the complete OR repertoire of the three study species and represents an important contribution to the understanding of the evolution and function of the sense of smell in vertebrates.
303646/2021-7 National Council for Scientific and Technological Development, 443892/2020-2 National Council for Scientific and Technological Development, Finance Code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, CAPES-PrInt) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Abaffy,
The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.
2007, Pubmed,
Xenbase
Abaffy,
The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues.
2007,
Pubmed
,
Xenbase Almeida-Silva,
syntenet: an R/Bioconductor package for the inference and analysis of synteny networks.
2023,
Pubmed Altschul,
Basic local alignment search tool.
1990,
Pubmed Bailey,
Fitting a mixture model by expectation maximization to discover motifs in biopolymers.
1994,
Pubmed Bailey,
The MEME Suite.
2015,
Pubmed Buck,
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition.
1991,
Pubmed Conant,
Turning a hobby into a job: how duplicated genes find new functions.
2008,
Pubmed Conceição,
High incidence of interchromosomal transpositions in the evolutionary history of a subset of or genes in Drosophila.
2008,
Pubmed Eirín-López,
The birth-and-death evolution of multigene families revisited.
2012,
Pubmed Fleischer,
Mammalian olfactory receptors.
2009,
Pubmed Freeman,
The giant pouched rat (Cricetomys ansorgei) olfactory receptor repertoire.
2020,
Pubmed Glusman,
The complete human olfactory subgenome.
2001,
Pubmed Guo,
Molecular evolution of Drosophila odorant receptor genes.
2007,
Pubmed Han,
Building the Chordata Olfactory Receptor Database using more than 400,000 receptors annotated by Genome2OR.
2022,
Pubmed Huang,
CD-HIT Suite: a web server for clustering and comparing biological sequences.
2010,
Pubmed Hughes,
The Birth and Death of Olfactory Receptor Gene Families in Mammalian Niche Adaptation.
2018,
Pubmed Jungblut,
Olfactory subsystems in the peripheral olfactory organ of anuran amphibians.
2021,
Pubmed
,
Xenbase Kalyaanamoorthy,
ModelFinder: fast model selection for accurate phylogenetic estimates.
2017,
Pubmed Katoh,
MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization.
2019,
Pubmed Khan,
Olfactory Receptor Subgenomes Linked with Broad Ecological Adaptations in Sauropsida.
2015,
Pubmed Krzywinski,
Circos: an information aesthetic for comparative genomics.
2009,
Pubmed Li,
Genomic and transcriptomic insights into molecular basis of sexually dimorphic nuptial spines in Leptobrachium leishanense.
2019,
Pubmed Li,
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences.
2006,
Pubmed Liedtke,
Macroevolutionary shift in the size of amphibian genomes and the role of life history and climate.
2018,
Pubmed Liu,
A Chromosome-Level Assembly of Blunt Snout Bream (Megalobrama amblycephala) Genome Reveals an Expansion of Olfactory Receptor Genes in Freshwater Fish.
2021,
Pubmed Lv,
Genome-Wide Identification and Characterization of Olfactory Receptor Genes in Chinese Perch, Siniperca chuatsi.
2019,
Pubmed Man,
Prediction of the odorant binding site of olfactory receptor proteins by human-mouse comparisons.
2004,
Pubmed McKenzie,
The genomic architecture and molecular evolution of ant odorant receptors.
2018,
Pubmed Medeiros,
Reproductive phenology of the American Bullfrog in subtropical Brazil: photoperiod as a main determinant of seasonal activity.
2016,
Pubmed Mombaerts,
Genes and ligands for odorant, vomeronasal and taste receptors.
2004,
Pubmed Nei,
The evolution of animal chemosensory receptor gene repertoires: roles of chance and necessity.
2008,
Pubmed Nei,
Concerted and birth-and-death evolution of multigene families.
2005,
Pubmed Niimura,
Evolutionary dynamics of olfactory receptor genes in chordates: interaction between environments and genomic contents.
2009,
Pubmed Niimura,
Olfactory receptor multigene family in vertebrates: from the viewpoint of evolutionary genomics.
2012,
Pubmed Niimura,
Identification of chemosensory receptor genes from vertebrate genomes.
2013,
Pubmed Niimura,
Identification of olfactory receptor genes from mammalian genome sequences.
2013,
Pubmed Niimura,
Extreme expansion of the olfactory receptor gene repertoire in African elephants and evolutionary dynamics of orthologous gene groups in 13 placental mammals.
2014,
Pubmed Niimura,
Acceleration of Olfactory Receptor Gene Loss in Primate Evolution: Possible Link to Anatomical Change in Sensory Systems and Dietary Transition.
2018,
Pubmed Niimura,
Evolution of olfactory receptor genes in the human genome.
2003,
Pubmed Niimura,
Evolutionary changes of the number of olfactory receptor genes in the human and mouse lineages.
2005,
Pubmed Niimura,
Evolutionary dynamics of olfactory receptor genes in fishes and tetrapods.
2005,
Pubmed Niimura,
Extensive gains and losses of olfactory receptor genes in mammalian evolution.
2007,
Pubmed Niimura,
On the origin and evolution of vertebrate olfactory receptor genes: comparative genome analysis among 23 chordate species.
2009,
Pubmed Niimura,
Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates.
2006,
Pubmed Nozawa,
Evolutionary dynamics of olfactory receptor genes in Drosophila species.
2007,
Pubmed Olender,
HORDE: comprehensive resource for olfactory receptor genomics.
2013,
Pubmed Ryan,
Patterns of mating call preferences in túngara frogs, Physalaemus pustulosus.
2007,
Pubmed Saito,
Evolution of Heat Sensors Drove Shifts in Thermosensation between Xenopus Species Adapted to Different Thermal Niches.
2016,
Pubmed
,
Xenbase Segerman,
The Most Frequently Used Sequencing Technologies and Assembly Methods in Different Time Segments of the Bacterial Surveillance and RefSeq Genome Databases.
2020,
Pubmed Stamatakis,
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies.
2014,
Pubmed Streicher,
The genome sequence of the common toad, Bufo bufo (Linnaeus, 1758).
2021,
Pubmed Sun,
Whole-genome sequence of the Tibetan frog Nanorana parkeri and the comparative evolution of tetrapod genomes.
2015,
Pubmed
,
Xenbase Touhara,
Deorphanizing vertebrate olfactory receptors: recent advances in odorant-response assays.
2007,
Pubmed Vandewege,
Contrasting Patterns of Evolutionary Diversification in the Olfactory Repertoires of Reptile and Bird Genomes.
2016,
Pubmed Wang,
Genome-wide identification and characterization of olfactory receptor genes in common carp (Cyprinus carpio).
2021,
Pubmed Weaver,
Datamonkey 2.0: A Modern Web Application for Characterizing Selective and Other Evolutionary Processes.
2018,
Pubmed Yang,
Codon-substitution models for detecting molecular adaptation at individual sites along specific lineages.
2002,
Pubmed Yang,
Repetitive element-mediated recombination as a mechanism for new gene origination in Drosophila.
2008,
Pubmed Yohe,
Olfactory receptor gene evolution is unusually rapid across Tetrapoda and outpaces chemosensory phenotypic change.
2020,
Pubmed Yohe,
Ecological constraints on highly evolvable olfactory receptor genes and morphology in neotropical bats.
2022,
Pubmed Young,
Different evolutionary processes shaped the mouse and human olfactory receptor gene families.
2002,
Pubmed Young,
Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.
2003,
Pubmed Young,
The sense of smell: genomics of vertebrate odorant receptors.
2002,
Pubmed Zhang,
PhyloSuite: An integrated and scalable desktop platform for streamlined molecular sequence data management and evolutionary phylogenetics studies.
2020,
Pubmed Zhang,
The olfactory receptor gene superfamily of the mouse.
2002,
Pubmed Zhang,
Odorant and vomeronasal receptor genes in two mouse genome assemblies.
2004,
Pubmed Zhang,
Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
2003,
Pubmed Zhao,
Network-based microsynteny analysis identifies major differences and genomic outliers in mammalian and angiosperm genomes.
2019,
Pubmed Zhou,
Characterization of olfactory receptor repertoires provides insights into the high-altitude adaptation of the yak based on the chromosome-level genome.
2022,
Pubmed
