Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression.
Moss FJ, Viard P, Davies A, Bertaso F, Page KM, Graham A, Cantí C, Plumpton M, Plumpton C, Clare JJ, Dolphin AC.
???displayArticle.abstract???
We have cloned and characterized a new member of the voltage-dependent Ca(2+) channel gamma subunit family, with a novel gene structure and striking properties. Unlike the genes of other potential gamma subunits identified by their homology to the stargazin gene, CACNG7 is a five-, and not four-exon gene whose mRNA encodes a protein we have designated gamma(7). Expression of human gamma(7) has been localized specifically to brain. N-type current through Ca(V)2.2 channels was almost abolished when co-expressed transiently with gamma(7) in either Xenopus oocytes or COS-7 cells. Furthermore, immunocytochemistry and western blots show that gamma(7) has this effect by causing a large reduction in expression of Ca(V)2.2 rather than by interfering with trafficking or biophysical properties of the channel. No effect of transiently expressed gamma(7) was observed on pre-existing endogenous N-type calcium channels in sympathetic neurones. Low homology to the stargazin-like gamma subunits, different gene structure and the unique functional properties of gamma(7) imply that it represents a distinct subdivision of the family of proteins identified by their structural and sequence homology to stargazin.
Ahern,
Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle.
2001, Pubmed
Ahern,
Modulation of L-type Ca2+ current but not activation of Ca2+ release by the gamma1 subunit of the dihydropyridine receptor of skeletal muscle.
2001,
Pubmed Amaya,
Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.
2000,
Pubmed Birnbaumer,
Structures and functions of calcium channel beta subunits.
1998,
Pubmed
,
Xenbase Black,
Identification and cloning of putative human neuronal voltage-gated calcium channel gamma-2 and gamma-3 subunits: neurologic implications.
1999,
Pubmed Brice,
Importance of the different beta subunits in the membrane expression of the alpha1A and alpha2 calcium channel subunits: studies using a depolarization-sensitive alpha1A antibody.
1997,
Pubmed Burge,
Prediction of complete gene structures in human genomic DNA.
1997,
Pubmed Burgess,
A cluster of three novel Ca2+ channel gamma subunit genes on chromosome 19q13.4: evolution and expression profile of the gamma subunit gene family.
2001,
Pubmed Burgess,
Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
1999,
Pubmed Cantí,
Identification of residues in the N terminus of alpha1B critical for inhibition of the voltage-dependent calcium channel by Gbeta gamma.
1999,
Pubmed
,
Xenbase Cantí,
Evidence for two concentration-dependent processes for beta-subunit effects on alpha1B calcium channels.
2001,
Pubmed
,
Xenbase Catterall,
Structure and regulation of voltage-gated Ca2+ channels.
2000,
Pubmed Chen,
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms.
,
Pubmed Chu,
Calcium channel gamma subunits provide insights into the evolution of this gene family.
2001,
Pubmed Delmas,
On the role of endogenous G-protein beta gamma subunits in N-type Ca2+ current inhibition by neurotransmitters in rat sympathetic neurones.
1998,
Pubmed Dolphin,
Mechanisms of modulation of voltage-dependent calcium channels by G proteins.
1998,
Pubmed Freise,
Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties.
2000,
Pubmed Gill,
A new dynamic tool to perform assembly of expressed sequence tags (ESTs).
1997,
Pubmed Jay,
Primary structure of the gamma subunit of the DHP-sensitive calcium channel from skeletal muscle.
1990,
Pubmed Jones,
Overview of voltage-dependent calcium channels.
1998,
Pubmed Kang,
Biochemical and biophysical evidence for gamma 2 subunit association with neuronal voltage-activated Ca2+ channels.
2001,
Pubmed
,
Xenbase Klugbauer,
A family of gamma-like calcium channel subunits.
2000,
Pubmed Kornau,
Interaction of ion channels and receptors with PDZ domain proteins.
1997,
Pubmed Lacerda,
T-type and N-type calcium channels of Xenopus oocytes: evidence for specific interactions with beta subunits.
1994,
Pubmed
,
Xenbase Letts,
The mouse stargazer gene encodes a neuronal Ca2+-channel gamma subunit.
1998,
Pubmed Meir,
Calcium channel beta subunit promotes voltage-dependent modulation of alpha 1 B by G beta gamma.
2000,
Pubmed Morales,
Actin-dependent regulation of neurotransmitter release at central synapses.
2000,
Pubmed Perez-Reyes,
Molecular characterization of a novel family of low voltage-activated, T-type, calcium channels.
1998,
Pubmed
,
Xenbase Plummer,
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons.
1989,
Pubmed Powers,
Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location.
1993,
Pubmed Raghib,
Dominant-negative synthesis suppression of voltage-gated calcium channel Cav2.2 induced by truncated constructs.
2001,
Pubmed Schorge,
Calcium channel activation stabilizes a neuronal calcium channel mRNA.
1999,
Pubmed Sharp,
Biochemical and anatomical evidence for specialized voltage-dependent calcium channel gamma isoform expression in the epileptic and ataxic mouse, stargazer.
2001,
Pubmed Swick,
Promoter-cDNA-directed heterologous protein expression in Xenopus laevis oocytes.
1992,
Pubmed
,
Xenbase Tomita,
PDZ protein interactions regulating glutamate receptor function and plasticity.
2001,
Pubmed
