Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
???displayArticle.abstract???
New evidence supports the idea of a nonmicrotubule spindle matrix, but the debate about the reality of this structure continues.
Figure 1. New evidence for a possible spindle matrix. Speckles of polymerized tubulin (top) move over time (top to bottom), whereas speckles of the kinesin motor Eg5 (bottom) stay stationary relative to the spindle. Thus, the Eg5 may be tethered by a spindle matrix.
Figure 2. Skeletor (red) forms a structure in the nucleus even before the formation of an extensive microtubule-based spindle (green). See http://www.jcb.org/cgi/content/full/151/7/1401/DC1 for related videos.
Bělař,
[Not Available].
1929,
Pubmed Dionne,
NuMA is a component of an insoluble matrix at mitotic spindle poles.
1999,
Pubmed
,
Xenbase Kapoor,
Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix.
2001,
Pubmed
,
Xenbase Leslie,
Kinesin is associated with a nonmicrotubule component of sea urchin mitotic spindles.
1987,
Pubmed Margolis,
The telophase disc: its possible role in mammalian cell cleavage.
1993,
Pubmed Merdes,
A complex of NuMA and cytoplasmic dynein is essential for mitotic spindle assembly.
1996,
Pubmed
,
Xenbase Paddy,
Spoke: a 120-kD protein associated with a novel filamentous structure on or near kinetochore microtubules in the mitotic spindle.
1991,
Pubmed Paweletz,
Walther Flemming: pioneer of mitosis research.
2001,
Pubmed Paweletz,
[On the function of the "Flemming body" during division of animal cells].
1967,
Pubmed Pickett-Heaps,
An extended corona attached to metaphase kinetochores of the green alga Oedogonium.
1993,
Pubmed Pickett-Heaps,
Rethinking mitosis.
1982,
Pubmed Schibler,
Mitosis in Oedogonium: spindle microfilaments and the origin of the kinetochore fiber.
1980,
Pubmed Scholey,
Mitosis, microtubules, and the matrix.
2001,
Pubmed Sharp,
The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles.
1999,
Pubmed Steffen,
Evidence for a non-tubulin spindle matrix and for spindle components immunologically related to tektin filaments.
1992,
Pubmed Subirana,
Role of spindle microtubules in mitosis.
1968,
Pubmed Walker,
Skeletor, a novel chromosomal protein that redistributes during mitosis provides evidence for the formation of a spindle matrix.
2000,
Pubmed Wright,
Subcellular localization and sequence of sea urchin kinesin heavy chain: evidence for its association with membranes in the mitotic apparatus and interphase cytoplasm.
1991,
Pubmed
