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Summary Expression Phenotypes Gene Literature (28) GO Terms (88) Nucleotides (63) Proteins (36) Interactants (402) Wiki
XB-GENEPAGE-490261
???displayGene.symbol???:
 alk

???displayGene.name???: 
ALK receptor tyrosine kinase

???displayGene.synonyms???
LOC108716096 , LOC108717382 , xalk ( Nomenclature history )

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Anaplastic lymphoma kinase (ALK) is a membrane receptor tyrosine kinase of the insulin receptor superfamily . The ALK gene is a locus of genomic instability and plays a pivotal role in tumorigenesis, where chromosomal rearrangements cause the fusion of its intracellular domain with other proteins (eg NPM or EML4).

AI Protein Function :
The alk protein is a receptor tyrosine kinase expressed in developing cranial ganglia, branchial arches, eyes, and somites. It functions as a membrane-bound receptor involved in neural crest cell migra...[+]


InterPro :
Protein kinase ATP BS, Kinase-like dom sf, Tyr kinase rcpt 2 CS, Prot kinase dom, [+]

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Diseases: 


Disease Ontology:
non-Hodgkin lymphoma [+]

MIM:
LYMPHOMA, NON-HODGKIN, FAMILIAL [+]

External Links:
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???displayGene.expression???                  Development Stages                                               Embryonic Tissues                                                                Adult Tissues
More Information
Xenbase Expression Details In situ images Single cell data at SPRING In situ: RNA-Seq:


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