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Many animal life histories entail changing feeding ecology, but the molecular bases for these transitions are poorly understood. The amphibian tadpole is typically a growth and dispersal life-history stage. Tadpoles are primarily herbivorous, and they capitalize on growth opportunities to reach a minimum body size to initiate metamorphosis. During metamorphic climax, feeding declines, at which time the gastrointestinal (GI) tract remodels to accommodate the carnivorous diet of the adult frog. Here we show that anorexigenic hypothalamic feeding controls are absent in the tadpole, but develop during metamorphosis concurrent with the production of the satiety signal leptin. Before metamorphosis there is a large increase in leptin mRNA in fat tissue. Leptin receptor mRNA increased during metamorphosis in the preoptic area/hypothalamus, the key brain region involved with the control of food intake and metabolism. This corresponded with an increase in functional leptin receptor, as evidenced by induction of socs3 mRNA and phosphorylated STAT3 immunoreactivity, and suppression of feeding behaviour after injection of recombinant frog leptin. Furthermore, we found that immunoneutralization of leptin in tadpoles at metamorphic climax caused them to resume feeding. The absence of negative regulation of food intake in the tadpole allows the animal to maximize growth prior to metamorphosis. Maturation of leptin-responsive neural circuits suppresses feeding during metamorphosis to facilitate remodelling of the GI tract.
Ahima,
Leptin signaling.
2004,
Pubmed Ahima,
Role of leptin in the neuroendocrine response to fasting.
1996,
Pubmed Ahima,
Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.
1998,
Pubmed Bagamasbad,
A role for basic transcription element-binding protein 1 (BTEB1) in the autoinduction of thyroid hormone receptor beta.
2008,
Pubmed
,
Xenbase Banks,
Activation of downstream signals by the long form of the leptin receptor.
2000,
Pubmed Baskin,
Leptin sensitive neurons in the hypothalamus.
1999,
Pubmed Bates,
The role of leptin receptor signaling in feeding and neuroendocrine function.
2003,
Pubmed Bender,
Leptin Induces Mitosis and Activates the Canonical Wnt/β-Catenin Signaling Pathway in Neurogenic Regions of Xenopus Tadpole Brain.
2017,
Pubmed
,
Xenbase Bender,
To eat or not to eat: ontogeny of hypothalamic feeding controls and a role for leptin in modulating life-history transition in amphibian tadpoles.
2018,
Pubmed
,
Xenbase Bjorbak,
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985.
2000,
Pubmed Bouret,
Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice.
2004,
Pubmed Bouret,
Development of hypothalamic neural networks controlling appetite.
2010,
Pubmed Bouret,
Development of leptin-sensitive circuits.
2007,
Pubmed Bouret,
Minireview: Leptin and development of hypothalamic feeding circuits.
2004,
Pubmed Bousquet,
Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing.
2000,
Pubmed Cottrell,
Postnatal development of hypothalamic leptin receptors.
2010,
Pubmed Cottrell,
Developmental changes in hypothalamic leptin receptor: relationship with the postnatal leptin surge and energy balance neuropeptides in the postnatal rat.
2009,
Pubmed Crespi,
Roles of stress hormones in food intake regulation in anuran amphibians throughout the life cycle.
2005,
Pubmed Crespi,
Leptin (ob gene) of the South African clawed frog Xenopus laevis.
2006,
Pubmed
,
Xenbase Crespi,
Development of food intake controls: neuroendocrine and environmental regulation of food intake during early life.
2014,
Pubmed Cui,
Ancient origins and evolutionary conservation of intracellular and neural signaling pathways engaged by the leptin receptor.
2014,
Pubmed
,
Xenbase Davis,
Gastric emptying and control of ingestion in preweanling rat pups.
2003,
Pubmed Denver,
Acceleration of anuran amphibian metamorphosis by corticotropin-releasing hormone-like peptides.
1993,
Pubmed Denver,
Environmental stress as a developmental cue: corticotropin-releasing hormone is a proximate mediator of adaptive phenotypic plasticity in amphibian metamorphosis.
1997,
Pubmed Denver,
Neuroendocrinology of amphibian metamorphosis.
2013,
Pubmed Denver,
Evolution of leptin structure and function.
2011,
Pubmed Elmquist,
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
1998,
Pubmed Flak,
Minireview: CNS Mechanisms of Leptin Action.
2016,
Pubmed Grove,
Development of metabolic systems.
2005,
Pubmed Maniam,
The link between stress and feeding behaviour.
2012,
Pubmed Manzon,
Regulation of pituitary thyrotropin gene expression during Xenopus metamorphosis: negative feedback is functional throughout metamorphosis.
2004,
Pubmed
,
Xenbase Melnick,
Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus.
2007,
Pubmed Mistry,
Leptin alters metabolic rates before acquisition of its anorectic effect in developing neonatal mice.
1999,
Pubmed Myers,
Mechanisms of leptin action and leptin resistance.
2008,
Pubmed Patterson,
Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells.
2011,
Pubmed Proulx,
Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake.
2002,
Pubmed Riul,
Ethological analysis of mother-pup interactions and other behavioral reactions in rats: effects of malnutrition and tactile stimulation of the pups.
1999,
Pubmed Shi,
Thyroid hormone-dependent regulation of the intestinal fatty acid-binding protein gene during amphibian metamorphosis.
1994,
Pubmed
,
Xenbase Stengel,
CRF and urocortin peptides as modulators of energy balance and feeding behavior during stress.
2014,
Pubmed Wilbur,
Ecological Aspects of Amphibian Metamorphosis: Nonnormal distributions of competitive ability reflect selection for facultative metamorphosis.
1973,
Pubmed Wright,
The fat body of bullfrog (Lithobates catesbeianus) tadpoles during metamorphosis: changes in mass, histology, and melatonin content and effect of food deprivation.
2011,
Pubmed
